Go to www.gsk.com then click Careers.  Select US and enter either WD61261 or ‘metabolism’ and the position will show up.

WD61261 – Senior/Principal Scientific Investigator – Drug Metabolism Mechanisms


Senior/Principal Scientific Investigator – Drug Metabolism Mechanisms

Requisition ID:



Full time

Open date:

Dec 23, 2015 2:36:21 PM

Functional area:

Science and Technology


King of Prussia, Pennsylvania

Job Posting Grade:


Required degrees:



Not Indicated

Eligible for employee referral bonus:


Employee referral bonus currency:

Employee referral bonus amount:



Basic qualifications: 

•PhD in Biochemistry, Biological or chemistry sciences
•3-5 years pharmaceutical industry experience
•Experience or working in matrix across departmental lines
•Extensive knowledge chemistry of biotransformation or metabolism, and ability to apply their experience to drug discovery, development or post-marketing area issues.
•Strong experience applying in vitro/ex-vivo technologies and in vitro/ex-vivo to in vivo extrapolation to investigative safety issues.
•Strong communication skills (e.g., writing, speaking) 
•Strong experience in project issue resolution relevant to drug safety and the development of novel scientific approaches for mechanistic investigation.

Preferred qualifications: 

•PhD with specilization in Drug Metabolism with application to drug discovery, development and registration of new molecular entities

•Demonstrated networking skills with external key opinion leaders and experts in scientific disciplines and effectively communicates findings to internal groups. 
Supports and develops others by acting as a coach or mentor, by allocating important projects and challenging responsibilities to others for the purpose of their development. 
•Strong communication skills (e.g., writing, speaking).  
•Ability to build strong communication networks, share knowledge effectively across departments and divisions and establish cross functional matrix groups.
•Strong leadership skills demonstrating vision and strategy


Job Purpose:

Provide deep scientific knowledge and expertise in xenobiotic biotransformation and metabolite formation mechanisms, and to work alongside other experts to relate these findings to the safety of medicines in patients. To act as a key opinion leader to the wider community of scientists across the MSD line, to PTS and the wider GSK.

Key Responsibilities:

• Develop the scientific strategy, along with other experts, to improve our understanding of xenobiotic chemistry and their biotransformation pathways (structural alerts) and how these link to biological mechanisms of toxicity and thus provide a better association of Molecular Initiating Events with Adverse Outcome Pathways e.g., xenobiotics effects on genome, proteome, metabolome, and what predisposes certain population to adverse events. 
• Collaborate with the Computational & Modelling Science group and the rest of MSD to integrate these findings into qualitative systems biology models and routinely discuss experiments to test hypotheses. 
• Work with Insight from Data and Computational & Modelling Science groups to use or to help create knowledge databases to develop SAR’s using retrospective and competitor information and establish relational rules for toxicity e.g. moiety x likely to be mutagenic (DEREK), covalent binding to proteins leading to idiosyncratic drug reactions. Use in silico predictions where possible.
• Advance our knowledge of the enzymes their impact on preclinical-clinical translation (species differences) and prediction of clinical variability in patient populations (polymorphisms, DDIs, impact of disease). 
• Evaluate/direct potential innovative drug metabolism/biotransformation research areas and/or apply innovative solutions to project problems, including design of bespoke studies and application of differential development.  Develop a scientific strategy in this area with a 12 – 18 month planning horizon.
• Contextualize and extrapolate drug metabolism/biotransformation findings and discuss data with program/project teams, internal advisory groups as well as Senior Leaders & Regulators
• Represent GSK on external working groups to advance our understanding of drug metabolism / biotransformation mechanisms from preclinical findings to the clinical setting by working with industry (e.g. cross-industry consortia, IQ, IMI,) and academia as well as regulatory groups. Closely follow and critique primary literature to maintain awareness
• Critique, influence and represent ‘ADME’ for PTS on a range of topics, including drug metabolism, biotransformation mechanisms, enzymology, modeling and, where appropriate drug transporters. 
• Communicate, interact and influence others and acts as mentor, coach, trainer and consultant in understanding biotransformation pathways.
• Publishes regularly in relevant journals and provide authorship/review of high quality reports, publications, regulatory dossiers